Aktuality
Odborný seminář: Praktické aspekty "counter current" chromatografie
Interní seminář: Cupper-free click reactions - current state of arte
Interní seminář: Possibility of novel linkers for SPOS
Interní seminář: New systems for fluorescent labeling of mitochondria
Interní seminář: Labile or resistant Rink resin
Interní seminář: Unexpected reaction or hydrazones on solid support under base treatment
Publikace v odborných časopisech
Messina, I.; Popa, I.; Maier, M.; Soural, M.:
Solid-Phase Synthesis of 5-Noranagrelide Derivatives
ACS Combinatorial Science 2014, 16 (1), 33-38
Cankarova, N.; Krchnak, V.
Solid-Phase Synthesis Enabling Chemical Diversity. In Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis
Kapitola v knize, Drug Discovery, and Chemical Biology, Trabocchi, A., Ed.; Wiley: 2013; pp 201-252.
Schütznerova, E.; Oliver, A. G.; Zajicek, J.; Krchnak, V.
Polymer-Supported Stereoselective Synthesis of (1S,5S)-6-oxa-3,8-iazabicyclo[3.2.1]octanes.
Eur. J. Org. Chem. 2013, 3158-3165.
La Venia, A.; Lemrova, B.; Krchnak, V.
Regioselective Incorporation of Backbone Constraints Compatible with Traditional Solid-Phase Peptide Synthesis
ACS Comb. Sci., 2013; 15 (1), 59-72.
La Venia,A. ; Dolensky, B.; Krchnak, V.
Polymer-Supported Stereoselective Synthesis of Tetrahydro-2H-oxazolo[3,2-a]pyrazin-5(3H)-ones from N-(2-Oxo-ethyl)-Derivatized Dipeptides via Eastbound Iminiums
ACS Comb. Sci., 2013; 15 (3); 162-167.
Kaplanek, R. ; Krchnak, V.
Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis
Tetrahedron Lett., 2013 54 (21); 2600-2603.
Křupková, S.; Funk, P.; Soural, M.; Hlaváč, J.
4-Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds
ACS Comb. Sci., 2013, 15, 20-28
Neagoie, C.; Krchnak, V.
Piperazine Amide Linker for Cyclative Cleavage for Solid Support: Traceless synthesis of dihydroquinoxalin-2-ones
ACS Comb. Sci., 2012, 14(7); 399-402.
Brulíková, L.; Hlaváč, J.; Hradil, P.
DNA interstrand cross-linking agents and their chemotherapeutic potential
Current Medicinal Chemistry 2011, accepted
Brulíková, L.; Hlaváč, J.
Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues
Beilstein Journal of Organic Chemistry 2011, 7, 678-698
Brulikova, L.; Dzubak, P.; Hajduch, M.; Hlavac, J.
Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study
Carbohydr. Res. 2011, accepted.
Vaňková, B.; Krchňák, V.; Soural, M.; Hlaváč, J.
Direct C-H Arylation of Purine on Solid Phase and Its Use for Chemical Libraries Synthesis
ACS Combinatorial Science, 2011, accepted
Motyka, K; Vaňková B.; Hlaváč, J; Soural, M.; Funk, P.
Purine Scaffold Effect on Fluorescence Properties of Purine-Hydroxyquinolinone Bisheterocycles
J. Fluoresc. 2011, accepted
Fülöpová, V.; Gucký T.; Grepl, M.; Soural, M.
Fülöpová, V.; Gucký T.; Grepl, M.; Soural, M.
ACS Combinatorial Science 2012, 12, 651-656
Cankařová, N.; Funk, P.; Hlaváč, J.; Soural, M.
Novel preloaded resins for solid-phase biotinylation of carboxylic acids
Tetrahedron Lett. 2011, accepted
Lemrova, B.; Soural, M.
Solid-Phase Synthesis of 4,7,8-Trisubstituted 1,2,3,4-Tetrahydro-benzo[e][1,4]diazepin-5-ones
ACS Combinatorial Science 2012, 14, 645-650
Soural,M.; Hradil P.; Křupková S.; Hlaváč J.
An Interesting Synthetic Pathway to Some Quinolin-4(1H)ones: Phenacylanthranilates Rearrangement – Limits and Scopes
Mini-Reviews in Organic Chemistry 2012, 9 (4), 426-432
Vaňková, B.; Brulíková, L.; Wu, B.; Krchňák, V.
Synthesis of Piperazinones, Piperazines, Tetrahydropyrazines, and Dihydropyrazinones from Polymer-Supported Acyclic Intermediates via N-Alkyl- and N-Acyliminiums
European Journal of Organic Chemistry 2012, 26, 5075-5084
Cankařová, N.; Krchňák, V.
Polymer-Supported Stereoselective Synthesis of Benzimidazolino- piperazinones
Journal of Organic Chemistry 2012, 77 (13), 5687-5695
Cagno, M.; Stein, P.C.; Stýskala, J.; Hlaváč, J.; Skalko-Basnet, N.; Brauer-Brandl, A.
Overcoming instability and low solubility of new cytostatic compounds: A comparsion of two approaches
Eur. J. Pharm. Biopharm. 2012, 80, 657-662.
Hlavac J.; Soural M.; Krchnak V.
Practical Aspects of Combinatorial Solid-Phase Synthesis (in Solid-Phase Organic Synthesis: Concepts, Strategies and Applications)
kapitola v knize, Wiley & Sons, Inc., 2012
Výsledky aplikovaného výzkumu - udělené patenty
Krejčí, P.; Hradil, P.; Hlaváč, J.; Hajdúch, M.
Derivatives 2-phenyl-3-hydroxyquinoline-4(1H)-ones and methods of their preparation and utilization
patent , US 8,299,092,B2
Krejčí, P.; Hradil, P.; Hlaváč, J.; Hajdúch, M.
Derivatives 2-phenyl-3-hydroxyquinoline-4(1H)-ones and methods of their preparation and utilization
patent, EP 2064200
Výsledky aplikovaného výzkumu - užitný vzor
Brulíková, L.; Motyka, K.; Hlaváč, J.
Fluorescent probe based on rhodamine-pyrimidine skeleton for the pH determination 24618
Univerzita Palackého, 2012
Brulíková, L.; Hlaváč, J.; Motyka, K.
The fluorescent probe of rhodamine-pyrimidine type for the determination of nitrite in water
užitný vzor , 25893 , Úřad průmyslového vlastnictví, 2013
Tento projekt je spolufinancován Evropským sociálním fondem a státním rozpočtem České republiky.
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